大鼠肾脏中肾单位对梗阻24小时的停流压力反应。
Nephron stop-flow pressure response to obstruction for 24 hours in the rat kidney.
作者信息
Arendshorst W J, Finn W F, Gottschalk C W
出版信息
J Clin Invest. 1974 May;53(5):1497-500. doi: 10.1172/JCI107699.
Abstract
Complete ureteral ligation of 24-h duration significantly reduced stop-flow and estimated glomerular capillary pressures in nephrons accessible to micropuncture in obstructed kidneys. In kidneys without ureteral obstruction, a similar response occurred in single tubules blocked for 24 h without affecting nearby unblocked tubules. Thus, the response to tubular obstruction occurs on an individual nephron basis and results from constriction of individual afferent arterioles. The mechanism leading to the response is unknown, but a feedback mechanism operating through the juxtaglomerular apparatus of individual nephrons is an attractive possibility.
摘要
持续24小时的完全输尿管结扎显著降低了梗阻肾脏中可进行微穿刺的肾单位的停流压和估计的肾小球毛细血管压。在没有输尿管梗阻的肾脏中，单个肾小管被阻塞24小时也会出现类似反应，且不影响附近未阻塞的肾小管。因此，对肾小管梗阻的反应是在单个肾单位的基础上发生的，是由单个入球小动脉的收缩引起的。导致这种反应的机制尚不清楚，但通过单个肾单位的球旁器起作用的反馈机制是一种很有吸引力的可能性。
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