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Kinetics and mechanisms of hydrolysis of 5-halouracils.

作者信息

Garrett E R, Nestler H J, Somodi A

出版信息

J Org Chem. 1968 Sep;33(9):3460-8. doi: 10.1021/jo01273a022.

DOI:10.1021/jo01273a022
PMID:5742874
Abstract
摘要

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Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
市售5-氟尿嘧啶药瓶的心脏毒性源于该药物的碱水解。
Br J Cancer. 1992 Jul;66(1):119-27. doi: 10.1038/bjc.1992.227.