Sytinskiĭ I A, Bezborodov A M, Blagova O E, Konovalova N N, Kopelevich V M
Vopr Biokhim Mozga. 1978;13:303-11.
Chronically alcoholized intoxication (1.5--2 months) induces adaptation of cerebral neurones to changing equilibrium states of biochemical processes by altering the activity of enzymes of GABA metabolism, reduction of alanine and aspartate transaminase activity and increase of LDH and succinate dehydrogenase activity. In the cerebellum and cerebral hemispheres during alcohol abstinacy the activity of GABA-T, succinate dehydrogenase and aspartate transaminase was reduced while that of LDH and alanine transaminase was increased. The administration of fusarinic acid (100 mg/kg i. p.) to control animals induced a sharp increase of GAD activity in both structures of the brain. The stimulatory effects of fusarinic acid were not observed when it was administered to animals receiving alcohol chronically. Motor activity or rats was markedly reduced during chronical alcoholism and the first days of alcohol abstinacy (24--48 h), as well as following injection fusarinic acid and homopantothenic acid. The increase of locomotion and the vertical component of motor activity was observed only following one week or one month after alcohol abstinacy.
长期酒精中毒（1.5 - 2个月）通过改变γ-氨基丁酸（GABA）代谢酶的活性、降低丙氨酸和天冬氨酸转氨酶活性以及增加乳酸脱氢酶（LDH）和琥珀酸脱氢酶活性，诱导大脑神经元适应生化过程不断变化的平衡状态。在戒酒期间，小脑和大脑半球中GABA转氨酶、琥珀酸脱氢酶和天冬氨酸转氨酶的活性降低，而LDH和丙氨酸转氨酶的活性增加。给对照动物腹腔注射100毫克/千克的镰刀菌酸会导致大脑两个结构中谷氨酸脱羧酶（GAD）活性急剧增加。当给长期饮酒的动物注射镰刀菌酸时，未观察到其刺激作用。在慢性酒精中毒期间以及戒酒的头几天（24 - 48小时），以及注射镰刀菌酸和高泛酸后，大鼠的运动活动明显减少。仅在戒酒一周或一个月后，才观察到运动能力和运动活动垂直分量的增加。
