Pennycuik P R, Fogerty A C, Willcox M E, Ferris M C, Baxter R I, Johnson A R
Aust J Biol Sci. 1979 Jun;32(3):309-16. doi: 10.1071/bi9790309.
Earlier studies with the random-bred Quackenbush mouse strain showed that human-type diets based on linoleic acid-enriched foodstuffs derived from ruminants fed protected polyunsaturated oils have no detrimental effects on growth, reproduction or longevity. Tumour incidence and time of onset of tumour development have now been studied in the inbred, tumour-prone mouse strain C3H, in addition to growth, reproduction and longevity. Mice were fed a polyunsaturated human diet, a conventional human diet, or mouse cubes. The results with C3H mice tended to confirm those with Quackenbush strain mice-growth rates and reproductive productivities were very similar in the two groups eating human diets. Mice on the conventional human diet tended to survive better to about 60 weeks of age than mice on the polyunsaturated diet or the cube diet, after which the mortality rates of the mice on the three diets were similar. The degree of unsaturation of the dietary fat had no significant effect on the incidence of tumours. The tumour incidence was about 40% which, taken in conjunction with the average age of onset (about 80 weeks), suggested that the NIV virus rather than the MMTV virus was responsible. It would appear that the high-fat human diets had no effect on the incidence of mammary tumours caused by this virus.
早期对随机繁殖的夸肯布什小鼠品系的研究表明，以富含亚油酸的食物为基础的人类型饮食，这些食物来源于喂食了受保护的多不饱和油的反刍动物，对生长、繁殖或寿命没有不利影响。除了生长、繁殖和寿命外，现在还对近交的、易患肿瘤的小鼠品系C3H的肿瘤发病率和肿瘤发生时间进行了研究。给小鼠喂食多不饱和人类饮食、传统人类饮食或小鼠方块饲料。C3H小鼠的结果倾向于证实夸肯布什品系小鼠的结果——两组食用人类饮食的小鼠的生长率和繁殖力非常相似。食用传统人类饮食的小鼠在60周龄左右往往比食用多不饱和饮食或方块饲料的小鼠存活得更好，在此之后，三种饮食的小鼠死亡率相似。饮食脂肪的不饱和度对肿瘤发病率没有显著影响。肿瘤发病率约为40%，结合平均发病年龄（约80周）来看，表明是NIV病毒而非MMTV病毒导致的。高脂肪的人类饮食似乎对这种病毒引起的乳腺肿瘤发病率没有影响。
