Dominic C J, Pandey S D
Endokrinologie. 1979 Apr;74(1):1-5.
The effect of cyproterone acetate (CA) on the production of the male-originating oestrus-inducing pheromone in the Indian field mouse, Mus booduga Gray was investigated. The anoestrus induced in regularly cycling females by unisexual grouping was reversed by exposure to intact males. The majority of male-exposed females returned to oestrus within seven days, with a peak on the fourth-day. By contrast, exposure to CA-treated males failed to induce oestrus in grouped females. Since CA is a potent antiandrogen, the inability of CA-treated males to induce oestrus in females is interpreted as due to the depression of the production of the androgen-dependent pheromone. The results provide evidence in favour of the concept that the oestrus-inducing pheromone in the Indian field mouse is associated with androgens either directly or indirectly through some androgen-dependent gland.
研究了醋酸环丙孕酮（CA）对印度田鼠（Mus booduga Gray）雄性来源的诱发发情信息素产生的影响。通过单性分组使正常发情周期的雌性进入发情间期，而暴露于完整雄性可使发情间期逆转。大多数暴露于雄性的雌性在七天内恢复发情，在第四天达到峰值。相比之下，暴露于经CA处理的雄性未能诱导分组雌性发情。由于CA是一种强效抗雄激素，经CA处理的雄性无法诱导雌性发情被解释为雄激素依赖性信息素产生受到抑制。结果提供了证据支持这样的概念，即印度田鼠中诱发发情的信息素直接或通过一些雄激素依赖性腺体与雄激素相关。
