Delini-Stula A, Vassout A
Eur J Pharmacol. 1979 Oct 15;58(4):443-51. doi: 10.1016/0014-2999(79)90315-7.
The study concerned the effects of maprotiline, imipramine, clomipramine and amitriptyline on the stereotyped and turning behaviour induced by apomorphine in rats. At either single or repeated doses of 25 mg/kg i.p. neither maprotiline nor imipramine changed the stereotyped responses induced by apomorphine. Clomipramine showed in contrast an inhibitory effect which increased after 7 daily injections of the drug. Moderate suppression of stereotypies was also observed after repeated administration of amitriptyline. In rats with unilateral 6-OHDA lesions of the s.nigra apomorphine-induced contralateral turning was markedly suppressed (70%) after a single 25 mg/kg i.p. injection of maprotiline. A tolerance to this effect developed after 7 daily injections of the drug. Clomipramine and amitriptyline caused an inhibition of turning which was markedly increased after repeated treatment. These results suggest that antidepressants do not uniformly affect the behavioural responses mediated by dopamine. Clomipramine and amitriptyline appear to possess dopamine receptor blocking properties which may become more pronounced after chronic treatment. In contrast, the dopamine receptor blockade by maprotiline diminished and disappeared under such conditions. Among the drugs investigated imipramine was the one which seemed to have the weakest influence on dopaminergic receptors.
该研究关注了马普替林、丙咪嗪、氯米帕明和阿米替林对阿扑吗啡诱导的大鼠刻板行为和旋转行为的影响。腹腔注射25mg/kg的单次或重复剂量时，马普替林和丙咪嗪均未改变阿扑吗啡诱导的刻板反应。相比之下，氯米帕明表现出抑制作用，且在每日注射该药物7次后作用增强。重复给予阿米替林后也观察到对刻板行为的中度抑制。在单侧黑质6-羟基多巴胺损伤的大鼠中，腹腔注射单次25mg/kg马普替林后，阿扑吗啡诱导的对侧旋转明显受到抑制（70%）。每日注射该药物7次后，对此效应产生了耐受性。氯米帕明和阿米替林引起旋转抑制，且重复治疗后抑制作用明显增强。这些结果表明，抗抑郁药并非均一地影响由多巴胺介导的行为反应。氯米帕明和阿米替林似乎具有多巴胺受体阻断特性，慢性治疗后这种特性可能会更加明显。相比之下，在这种情况下，马普替林的多巴胺受体阻断作用减弱并消失。在所研究的药物中，丙咪嗪似乎对多巴胺能受体的影响最弱。
