Hao X Z, Mathé A A, Mathé J M, Svensson T H
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Psychopharmacology (Berl). 1990;100(1):135-7. doi: 10.1007/BF02245805.
Electroconvulsive treatment (ECT) of mice, once daily for 7 days, significantly reduced the stimulation of motor activity induced by the selective dopamine (DA) D1-receptor agonist SKF 38393 (15 mg/kg IP), but significantly increased the motor stimulation by the unselective DA-receptor agonist apomorphine (1.5 mg/kg IP) in reserpine-treated (10 mg/kg IP) mice, when compared to control mice, receiving sham ECT. The results provide a functional correlate to previously observed ECT-induced down-regulation of D1 receptor sites in DA-rich regions of the rodent brain. Such an effect may be significant for clinical actions of ECT in affective disorders and, possibly, in Parkinson's disease.
对小鼠进行电休克治疗（ECT），每天一次，持续7天，与接受假ECT的对照小鼠相比，显著降低了选择性多巴胺（DA）D1受体激动剂SKF 38393（15毫克/千克腹腔注射）诱导的运动活性刺激，但显著增加了利血平（10毫克/千克腹腔注射）处理的小鼠中由非选择性DA受体激动剂阿扑吗啡（1.5毫克/千克腹腔注射）引起的运动刺激。这些结果为先前观察到的ECT诱导的啮齿动物脑富含DA区域D1受体位点下调提供了功能相关性。这种效应可能对ECT在情感障碍以及可能在帕金森病中的临床作用具有重要意义。
