Graff-Lonnevig V
J Allergy Clin Immunol. 1979 Dec;64(6 Pt 1):534-8. doi: 10.1016/0091-6749(79)90064-2.
Eighteen children aged 8 to 14 years with bronchial asthma were studied with respect to the diurnal variation in pulmonary expiratory flow and the influence on it of inhalation of Freons and of a beta 2-receptor stimulator, fenoterol. A double-blind technique and randomized order of the different conditions were used. Dynamic spirometric tests were performed every hour from 8 A.M. to 4 P.M. The low expiratory flow in the morning increased during the day and influenced the estimated duration of the beta 2-receptor stimulator. This must be taken into consideration when evaluating the long-term effect of bronchodilator drugs. The Freons acted as irritants and lowered the expiratory flow during the first 2 hr after inhalation. However, this impairment of lung function does not seem to be of any clinical importance when freons are used as propellants for potent beta 2-receptor stimulators such as fenoterol.
对18名8至14岁的支气管哮喘儿童进行了研究，观察其肺呼气流量的昼夜变化以及氟利昂吸入和β2受体激动剂非诺特罗对其的影响。采用了双盲技术和不同条件的随机顺序。从上午8点到下午4点每小时进行一次动态肺量计测试。早晨的低呼气流量在白天增加，并影响了β2受体激动剂的估计持续时间。在评估支气管扩张药物的长期效果时必须考虑到这一点。氟利昂起刺激物作用，在吸入后的前2小时内降低呼气流量。然而，当氟利昂用作强力β2受体激动剂如非诺特罗的推进剂时，这种肺功能损害似乎没有任何临床意义。
