Carpentiere G, Marino S, Castello F
Chest. 1983 Feb;83(2):211-4. doi: 10.1378/chest.83.2.211.
Metered-dose aerosol treatment with fenoterol for three consecutive days, in eight patients suffering from allergic asthma, caused the disappearance of FEV1 and MEF50 circadian rhythm. We attribute such behavior to the suppression of the bronchomotor tone induced by fenoterol. The administration on different days of a single dose of fenoterol aerosol in another group of eight patients pointed out the variability of the effects of the drug at different hours of the day. We believe the results obtained are important for a better dosage and time distribution of the therapy with beta2 agonists.
对8名过敏性哮喘患者连续3天使用非诺特罗定量气雾剂治疗，导致第一秒用力呼气容积（FEV1）和最大呼气中期流速（MEF50）的昼夜节律消失。我们将这种现象归因于非诺特罗引起的支气管运动张力抑制。在另一组8名患者中，于不同日期单次给予非诺特罗气雾剂，结果表明该药物在一天中不同时间的效果存在差异。我们认为所获得的结果对于优化β2激动剂治疗的剂量和时间分布具有重要意义。
