痘病毒核糖核酸聚合酶的诱导
Induction of poxvirus ribonucleic acid polymerases.
作者信息
Pitkanen A, McAuslan B, Hedgpeth J, Woodson B
出版信息
J Virol. 1968 Dec;2(12):1363-7. doi: 10.1128/JVI.2.12.1363-1367.1968.
Abstract
Two distinct ribonucleic acid polymerase activities were induced in HeLa cells by poxvirus infection. These activities differ both in their properties and the time of their appearance after infection. One catalyzes the dAT (copolymer of deoxyadenylate and deoxythymidylate)-primed conversion of adenosine triphosphate and uridine triphosphate into an acid-insoluble product. This enzyme is detectable only if deoxyribonucleic acid synthesis has been blocked. In contrast, the accumulation of progeny genomes is a necessary condition for induction of the second enzyme. The latter activity, which is unmasked by detergent treatment, is found exclusively in maturing virus particles. The possibility that both enzymes are involved in transcribing the viral genome is discussed.
摘要
痘病毒感染可在海拉细胞中诱导出两种不同的核糖核酸聚合酶活性。这些活性在其性质以及感染后出现的时间上均有所不同。一种催化以dAT（脱氧腺苷酸和脱氧胸苷酸的共聚物）为引物，将三磷酸腺苷和三磷酸尿苷转化为酸不溶性产物。仅当脱氧核糖核酸合成被阻断时才能检测到这种酶。相比之下，子代基因组的积累是诱导第二种酶的必要条件。后一种活性经去污剂处理后显现出来，仅在成熟病毒颗粒中发现。文中讨论了这两种酶都参与转录病毒基因组的可能性。
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