Tubiana M, Milhaud G, Coutris G, Lacour J, Parmentier C, Bok B
Br Med J. 1968 Oct 12;4(5623):87-9. doi: 10.1136/bmj.4.5623.87.
Seven patients with medullary carcinoma of the thyroid were investigated, and the thyrocalcitonin activity of the primary tumours, metastatic deposits, and the serum was estimated.Medullary carcinomas of the thyroid with amyloid stroma contain 100 to 600 times more thyrocalcitonin than normal thyroid tissue, and lymph nodes with metastatic deposits are equally rich in the hormone. High values of thyrocalcitonin are also found in the blood of these patients. Medullary carcinoma of the thyroid with amyloid stroma is the first disease to be recognized in which there is hypersecretion of thyrocalcitonin.
对7例甲状腺髓样癌患者进行了研究，并测定了原发肿瘤、转移灶及血清中的降钙素活性。伴有淀粉样基质的甲状腺髓样癌所含降钙素比正常甲状腺组织多100至600倍，有转移灶的淋巴结中该激素含量也同样丰富。这些患者的血液中也发现降钙素值升高。伴有淀粉样基质的甲状腺髓样癌是首个被确认存在降钙素分泌过多的疾病。
