Nagasawa H
Med Hypotheses. 1979 Oct;5(10):1117-21. doi: 10.1016/0306-9877(79)90027-6.
Experimentally, it has been found that the rate of DNA synthesis of normal mammary glands which is a limiting factor for mammary tumourigenesis is largely dependent upon the circulating level of prolactin. Based on these results, one of the roles of prolactin in the development of mammary tumours is hypothesized to create mammary gland conditions favourable for the action of carcinogens through its stimulation of the rate of mammary gland DNA synthesis, a measure of the frequency of mammary gland cell division.
实验发现，正常乳腺的DNA合成速率是乳腺肿瘤发生的一个限制因素，它在很大程度上取决于催乳素的循环水平。基于这些结果，推测催乳素在乳腺肿瘤发生过程中的作用之一是通过刺激乳腺DNA合成速率（一种衡量乳腺细胞分裂频率的指标），创造有利于致癌物作用的乳腺条件。
