吗啡戒断期间，大鼠纹状体内脑啡肽水平降低。

Enkephalin levels decrease in rat striatum during morphine abstinence.

作者信息

Bergström L, Terenius L

出版信息

Eur J Pharmacol. 1979 Dec 20;60(4):349-52. doi: 10.1016/0014-2999(79)90240-1.

Abstract

Male Sprague-Dawley rats were treated with morphine for 11 days. Saline-injected animals served as controls. The striatal enkephalin levels were measured with a radioimmunoassay 2, 24 and 48 h after withdrawal. There was no change 2 h after the last morphine injection, but a marked reduction after 24 h and a slight decrease after 48 h. No decrease in enkephalin levels was found 12 and 24 h after a single dose of 20 mg/kg morphine.

摘要

雄性Sprague-Dawley大鼠接受吗啡治疗11天。注射生理盐水的动物作为对照。在撤药后2小时、24小时和48小时，用放射免疫分析法测量纹状体脑啡肽水平。最后一次注射吗啡后2小时没有变化，但24小时后显著降低，48小时后略有下降。单次注射20mg/kg吗啡后12小时和24小时未发现脑啡肽水平降低。