Merrill J M, Brereton H D, Kent C H, Johnson R E
Lancet. 1976 May 22;1(7969):1105-7. doi: 10.1016/s0140-6736(76)90066-0.
A frequent and previously uncharacterised association of anorectal inflammatory disease in seven of twenty-two patients undergoing therapy for nonhaematological malignancy is described. Sepsis and secondary pulmonary infection were distant complications of the anorectal lesions. The degree of granulocytopenia induced by chemotherapy appears to be the major predisposing factor. Management includes early surgical intervention, and preventive measures specific for this patient population.
本文描述了22例接受非血液系统恶性肿瘤治疗的患者中，有7例出现了一种常见但此前未被描述的肛肠炎性疾病关联情况。脓毒症和继发性肺部感染是肛肠病变的远隔并发症。化疗引起的粒细胞减少程度似乎是主要的易感因素。治疗措施包括早期手术干预以及针对该患者群体的预防措施。
