Earle M F, Fossieck B E, Cohen M H, Ihde D C, Bunn P A, Minna J D
JAMA. 1981 Nov 27;246(21):2464-6.
Fifteen anorectal infections occurred in 6.4% of 188 intensively treated patients with small cell bronchogenic carcinoma. Granulocytopenia was present at onset in 13 episodes. In eight episodes, perirectal pain preceded any objective findings by two to 11 days. Ten infections resolved with recovery from granulocytopenia, but the five abscesses required incision. Septicemia accompanied four episodes; one patient died. Early recognition and therapy of this potentially fatal infection will become increasingly important as more patients with solid tumors receive intensive therapy.
188例接受强化治疗的小细胞支气管肺癌患者中，15例发生了肛门直肠感染，占6.4%。13例发病时存在粒细胞减少。8例在出现任何客观体征前2至11天有直肠周围疼痛。10例感染随着粒细胞减少的恢复而消退，但5例脓肿需要切开引流。4例伴有败血症；1例患者死亡。随着越来越多的实体瘤患者接受强化治疗，早期识别和治疗这种潜在致命感染将变得越来越重要。
