食粪对家兔胆汁酸代谢的影响。
Effect of coprophagy on bile acid metabolism in the rabbit.
作者信息
Yahiro K, Setoguchi T, Katsuki T
出版信息
Gastroenterol Jpn. 1979 Dec;14(6):545-52. doi: 10.1007/BF02773713.
The effect of coprophagy on the 7 alpha-dehydroxylation of biliary bile acids was studied in the rabbit. Bile acid composition of bile and intestinal contents was analyzed by gas-liquid chromatography and thin layer chromatography. Biliary bile acid composition of normal rabbits (n = 5) was: deoxycholic acid, 95.3 +/- 1.0SE % and cholic acid, 2.3 +/- 1.1SE %. When coprophagy was prevented, significant alterations were observed in biliary bile acid composition, including a considerable decrease in deoxycholic acid (82.5 +/- 2.8SE %, p less than 0.01) and a marked increase in cholic acid (15.2 +/- 3.0SE %, p less than 0.002). These results indicate that coprophagy is a factor causing an increase of the 7 alpha-dehydroxylated bile acid, deoxycholic acid (and lithocholic acid when the animals were fed chenodeoxycholic acid) in rabbit bile.
在兔子身上研究了食粪对胆汁酸7α-脱羟基作用的影响。通过气液色谱法和薄层色谱法分析胆汁和肠道内容物中的胆汁酸组成。正常兔子（n = 5）的胆汁胆汁酸组成如下：脱氧胆酸，95.3±1.0SE%；胆酸，2.3±1.1SE%。当阻止食粪时，观察到胆汁胆汁酸组成有显著变化，包括脱氧胆酸显著减少（82.5±2.8SE%，p<0.01）和胆酸显著增加（15.2±3.0SE%，p<0.002）。这些结果表明，食粪是导致兔胆汁中7α-脱羟基胆汁酸、脱氧胆酸（以及当动物喂食鹅去氧胆酸时的石胆酸）增加的一个因素。
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