Sink J D, Wechsler A S, Pellom G L, Thompson W M
Invest Radiol. 1979 Nov-Dec;14(6):508-12. doi: 10.1097/00004424-197911000-00011.
The isolated rat heart model was used to examine the effect of a new nonionic contrast agent, B-15,000 (Iopamidol), on cardiac function. Comparative studies were performed with Amipaque, Renografin 60, Renografin 76, and Vascoray. The three ionic contrast agents had significantly greater detrimental effects on cardiac function than either nonionic agent. The results support the continued evaluation of the nonionic agents for use in coronary angiography.
采用离体大鼠心脏模型来研究一种新型非离子型造影剂B - 15000(碘帕醇)对心脏功能的影响。与阿米培克、泛影葡胺60、泛影葡胺76和维塞瑞进行了对比研究。三种离子型造影剂对心脏功能的有害影响明显大于任何一种非离子型造影剂。这些结果支持继续评估非离子型造影剂在冠状动脉造影中的应用。