51铬（III）和51铬（VI）在大鼠体内的胆汁排泄与分布

Biliary excretion and distribution of 51Cr(III) and 51Cr(VI) in rats.

作者信息

Cikrt M, Bencko V

出版信息

J Hyg Epidemiol Microbiol Immunol. 1979;23(3):241-6.

Abstract

The biliary excretion and distribution of 51Cr after intravenous administration of 51Cr(III) (61CrCl5) or 51Cr(VI) (Na252CrO4 . 4 H2O) was studied in rats. The cumulative biliary excretion of 51Cr reached 24 hrs after the injection was significantly higher after administration of 51Cr(VI) than after 51Cr(III) 3.51+/-0.7% and 0.51+/-0.05% of administered dose, respectively). This difference was especially due to a higher rate of biliary excretion of 51Cr in the first hours after 51Cr(VI) administration. The excretion of 51Cr via faeces was also higher after administration of 51Cr(VI) (7.35+/-0.45%) OF ADMINISTERED DOSE, AS AGAINST 4.23+/-0.23% after 51Cr(III). On the other hand, no significant difference in urinary excretion of 51Cr was found. Statistically significant differences were also observed in the distribution of 51Cr in the organism after administration of both valence states of the metal.

摘要

在大鼠中研究了静脉注射51Cr(III)（61CrCl5）或51Cr(VI)（Na252CrO4·4H2O）后51Cr的胆汁排泄和分布情况。注射后24小时，51Cr的累积胆汁排泄量在给予51Cr(VI)后显著高于给予51Cr(III)后（分别为给药剂量的3.51±0.7%和0.51±0.05%）。这种差异尤其归因于51Cr(VI)给药后最初几小时内较高的胆汁排泄率。给予51Cr(VI)后，51Cr经粪便的排泄量也更高（为给药剂量的7.35±0.45%），而给予51Cr(III)后为4.23±0.23%。另一方面，未发现51Cr尿排泄有显著差异。在给予金属的两种价态后，51Cr在机体中的分布也观察到统计学上的显著差异。