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Acta Vet Scand. 1968;9(4):350-63. doi: 10.1186/BF03547862.
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引用本文的文献

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2
Studies on Aspergillus fumigatus; hydrolysis of polyamino acids by mycelial filtrate and chromatographic fractionation of the filtrate.烟曲霉研究；菌丝体滤液对聚氨基酸的水解及滤液的色谱分离
Acta Vet Scand. 1969;10(3):255-74. doi: 10.1186/BF03548277.
3
Studies of Aspergillus fumigatus; casein precipitating and proteolytic effects of mycelial filtrate.烟曲霉的研究；菌丝体滤液的酪蛋白沉淀和蛋白水解作用。
Acta Vet Scand. 1969;10(1):18-35. doi: 10.1186/BF03548293.
4
Fungal toxins as a parasitic factor responsible for the establishment of fungal infections.真菌毒素作为导致真菌感染发生的一种寄生因素。
Mycopathologia. 1978 Dec 18;65(1-3):141-54. doi: 10.1007/BF00447185.

本文引用的文献

1
Thiol groups of biological importance.具有生物学重要性的硫醇基团。
Adv Enzymol Relat Subj Biochem. 1951;11:201-66. doi: 10.1002/9780470122563.ch4.
2
EFFECT OF ASPERGILLUS FUMIGATUS ENDOTOXIN ON THE RESPIRATION AND PHOSPHORYLATION OF KIDNEY TISSUE.
Arch Biochem Biophys. 1965 Apr;110:23-31. doi: 10.1016/0003-9861(65)90150-5.
3
CHROMATOGRAPHIC FRACTIONATION OF ASPERGILLUS ENDOTOXINS.曲霉菌内毒素的色谱分离
Mycopathol Mycol Appl. 1963 Oct 30;20:272-86. doi: 10.1007/BF02089214.
4
FURTHER STUDIES OF THE ASPERGILLUS ENDOTOXINS.曲霉菌内毒素的进一步研究
Mycopathol Mycol Appl. 1963 Oct 30;20:253-71. doi: 10.1007/BF02089213.
5
Preparation and properties of the endotoxins of Aspergillus fumigatus and Aspergillus flavus.烟曲霉和黄曲霉内毒素的制备及性质
Mycopathol Mycol Appl. 1961 Aug 19;14:325-46. doi: 10.1007/BF02051548.
6
Studies on Aspergillus fumigatus, experimental mycotoxicosis in mice, chicks and pigs wth the appearance, in pigs, of perirenal edema.
Acta Vet Scand. 1966;7(1):21-34. doi: 10.1186/BF03547095.
7
Studies on Aspergillus fumigatus; toxin production by different strains and serological comparison of the strains.烟曲霉研究；不同菌株的毒素产生及菌株的血清学比较
Acta Vet Scand. 1965;6(3):224-33. doi: 10.1186/BF03547079.

烟曲霉研究；粗滤液中溶血素和毒素的稳定性

Studies on Aspergillus fumigatus; stability of haemolysin and toxin in crude filtrate.

作者信息

Rutqvist L

出版信息

Acta Vet Scand. 1968;9(4):350-63. doi: 10.1186/BF03547862.

DOI:10.1186/BF03547862
PMID:5752947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8753735/
Abstract

The haemolysin and toxin in mycelial filtrates of Aspergillus fumigatus showed a distinct difference in stability when the filtrate was heated at 60°C and pH 6.7, as well as at 40 °C and pH 9.5, the toxin being more stable. When the filtrate was heated at 40 °C and pH 2.5, a rapid inactivation of both haemolysin and toxin occurred. No haemolytic or toxic activity could be demonstrated in a filtrate with a 6 × 10M concentration of formalin after incubation at 37 °C for 3 and 4 days, respectively. Serum prepared with formalin-treated filtrate as antigen had a haemolysin- and toxin-neutralizing effect. When mercury chloride or p-chloromercuribenzoate in a final concentration of 10M was added to the filtrate, immediate blocking of the haemolytic activity, but not of the toxic, was obtained. Haemolysin inactivated by mercury in a final concentration of 10M was reactivated under the influence of L-cysteine or glutathione in a final concentration of 10M.

摘要

烟曲霉菌丝体滤液中的溶血素和毒素在滤液于60°C和pH 6.7以及40°C和pH 9.5加热时，稳定性表现出明显差异，毒素更稳定。当滤液在40°C和pH 2.5加热时，溶血素和毒素均迅速失活。分别在37°C孵育3天和4天后，浓度为6×10M的福尔马林处理的滤液中未显示出溶血或毒性活性。用福尔马林处理的滤液作为抗原制备的血清具有溶血素和毒素中和作用。当向滤液中加入终浓度为10M的氯化汞或对氯汞苯甲酸时，可立即阻断溶血活性，但不能阻断毒性。终浓度为10M的汞使溶血素失活后，在终浓度为10M的L-半胱氨酸或谷胱甘肽的影响下可重新激活。