人体药物水平的遗传控制：保泰松。

Genetic control of drug levels in man: phenylbutazone.

作者信息

Vesell E S, Page J G

出版信息

Science. 1968 Mar 29;159(3822):1479-80. doi: 10.1126/science.159.3822.1479.

DOI:10.1126/science.159.3822.1479

Abstract

Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.

摘要

给七对同卵双胞胎和七对异卵双胞胎服用了保泰松。个体半衰期为1.2至7.3天。具有相同基因型的受试者（同卵双胞胎）表现出非常相似的保泰松半衰期；而异卵双胞胎的半衰期差异则显著更大。先前确定的个体间保泰松代谢的巨大差异似乎是由基因而非环境决定的。