人体药物水平的遗传控制：安替比林

Genetic control of drug levels in man: antipyrine.

作者信息

Vesell E S, Page J G

出版信息

Science. 1968 Jul 5;161(3836):72-3. doi: 10.1126/science.161.3836.72.

DOI:10.1126/science.161.3836.72

Abstract

Antipyrine was administered to identical or monozygotic twins and to fraternal or dizygotic twins. Individuals with identical genotypes (monozygotic twins) exhibited significantly less variability in antipyrine halflife than did genetically different individuals (dizygotic twins). Therefore variations in antipyrine metabolism appear to be determined genetically rather than environmentally. In the 36 twins tested, antipyrine half-lives varied between 5.1 and 16.7 hours. No significant correlation occurred between half-lives for phenylbutazone and antipyrine in the 28 twins who received both drugs.

摘要

向同卵双胞胎或单卵双胞胎以及异卵双胞胎或双卵双胞胎施用了安替比林。具有相同基因型的个体（同卵双胞胎）在安替比林半衰期方面表现出的变异性明显低于基因不同的个体（异卵双胞胎）。因此，安替比林代谢的差异似乎是由基因决定的，而非环境因素。在接受测试的36对双胞胎中，安替比林半衰期在5.1至16.7小时之间变化。在同时接受两种药物的28对双胞胎中，保泰松和安替比林的半衰期之间未发现显著相关性。