Yano I, Nishino H, Murano T
Jpn J Pharmacol. 1979 Jun;29(3):357-66. doi: 10.1254/jjp.29.357.
The effect of naloxone given at various times after morphine administration on the development of tolerance to and dependence on a single dose of morphine was studied. Naloxone antagonized the analgesic effect of morphine and the development of tolerance to and dependence on morphine, dose dependently. The time course of the development of tolerance to a single dose of morphine almost paralleled that of dependence on morphine but the time course of the disappearance of tolerance did not coincide with that of dependence. When start of the duration of action of morphine was blocked by naloxone for various time intervals, the degree of tolerance to and dependence on morphine was antagonized, time dependently. When the end of the duration of action of morphine was antagonized by naloxone for various time intervals, tolerance and dependence which developed up to that time was completely antagonized by naloxone.
研究了吗啡给药后不同时间给予纳洛酮对单次剂量吗啡耐受性和依赖性形成的影响。纳洛酮剂量依赖性地拮抗吗啡的镇痛作用以及对吗啡的耐受性和依赖性的形成。单次剂量吗啡耐受性形成的时间进程几乎与吗啡依赖性的时间进程平行，但耐受性消失的时间进程与依赖性的时间进程不一致。当纳洛酮在不同时间间隔阻断吗啡作用持续时间的开始时，对吗啡的耐受性和依赖性程度呈时间依赖性地被拮抗。当纳洛酮在不同时间间隔拮抗吗啡作用持续时间的结束时，直至此时所形成的耐受性和依赖性被纳洛酮完全拮抗。
