Chapin J L, Newton J E
Pavlov J Biol Sci. 1979 Jan-Mar;14(1):1-9. doi: 10.1007/BF03001811.
There is evidence that cardiac arrhythmias are partially of CNS origin, and that certain drugs affect arrhythmia, both positively and negatively, through CNS action. We hypothesized and confirmed that chlordiazepoxide diminished the well-established incidence of arrhythmias (A-V blocks and nodal escapes) in five nervous pointer dogs. It is known that this drug normalizes behavior and aids in the bar-pressing performance of nervous dogs. Nervous dogs tend to have low heart rates (HRs) while normals have higher HRs. Chlordiazepoxide increased HRs in our five nervous dogs, and we postulated that HR increase would be less or none in normals. This was confirmed in a later study of five normals. A further study of eight normal dogs and eight nervous dogs essentially reproduced these findings, suggesting the possibility that the slow heart rates and the behavioral abnormality have a common basis, expected to be some CNS biochemical lesion.
有证据表明心律失常部分起源于中枢神经系统，并且某些药物通过中枢神经系统作用对心律失常产生正反两方面的影响。我们假设并证实了氯氮卓可降低五只神经质指示犬中已确定的心律失常（房室传导阻滞和结性逸搏）发生率。已知这种药物可使行为正常化，并有助于神经质犬的压杆行为表现。神经质犬的心率往往较低，而正常犬的心率较高。氯氮卓使我们的五只神经质犬的心率增加，我们推测正常犬心率的增加会较少或不增加。这在后来对五只正常犬的研究中得到了证实。对八只正常犬和八只神经质犬的进一步研究基本上重现了这些发现，这表明心率缓慢和行为异常可能有共同的基础，预计是某种中枢神经系统生化损伤。
