新城疫病毒对宿主细胞蛋白质和核糖核酸合成的抑制作用。
Inhibition of host-cell protein and ribonucleic acid synthesis by Newcastle disease virus.
作者信息
Wilson D E
出版信息
J Virol. 1968 Jan;2(1):1-6. doi: 10.1128/JVI.2.1.1-6.1968.
The mechanisms of Newcastle disease virus-(NDV) induced inhibition of cell protein and ribonucleic acid (RNA) synthesis were investigated. It was observed that the ability of NDV to inhibit cell RNA synthesis is dependent on the virus strain. The inhibitors, azauridine and cycloheximide, were added to cell cultures at different times after infection to study the roles of protein and RNA synthesis in the viral inhibition process. Viral inhibition of cell RNA synthesis and viral inhibition of cell protein synthesis become resistant to cycloheximide at a different time after infection than that in which they become resistant to azauridine. The results indicate that the inhibition of cell RNA synthesis by the Texas strain involves the synthesis of inhibitory proteins which are coded by the viral genome. The Texas and Beaudette strains of NDV appear to employ different mechanisms for the inhibition of host-cell protein synthesis. Viral inhibition of cell protein synthesis does not appear to cause, or be the result of, viral inhibition of cell RNA synthesis.
对新城疫病毒（NDV）诱导的细胞蛋白质和核糖核酸（RNA）合成抑制机制进行了研究。观察到NDV抑制细胞RNA合成的能力取决于病毒株。在感染后的不同时间向细胞培养物中添加抑制剂氮杂尿苷和环己酰亚胺，以研究蛋白质和RNA合成在病毒抑制过程中的作用。病毒对细胞RNA合成的抑制和病毒对细胞蛋白质合成的抑制在感染后的不同时间对环己酰亚胺产生抗性，这与它们对氮杂尿苷产生抗性的时间不同。结果表明，德州株对细胞RNA合成的抑制涉及由病毒基因组编码的抑制性蛋白质的合成。NDV的德州株和博德特株似乎采用不同的机制来抑制宿主细胞蛋白质合成。病毒对细胞蛋白质合成的抑制似乎不是病毒对细胞RNA合成抑制的原因，也不是其结果。
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