干扰素诱导和干扰素信使核糖核酸的产生动力学以及对放线菌酮和放线菌素D的敏感性
The dynamics of production and the sensitivity to cycloheximide and actinomycin D of interferon-inducing and interferon messenger RNA.
作者信息
Orlova T G, Kognovitskaya A I, Georgadze I I, Solovyov V D
出版信息
Acta Virol. 1976 Feb;20(1):9-14.
In the process of virus-induced interferon production, two kinds of RNA appear in the cells. One of them induces production by the recipient cells of interferon with the species-specificity of the latter cells (interferon-inducing RNA), and the other is translated by the recipient cells pre-treated with actinomycin D into interferon with the species-specificity of the donor cells of RNA (interferon mRNA). The interferon-inducing RNA appears 20-30 minutes after virus induction and shows maximal activity after 1 hour. Its formation is not influenced by cycloheximide or actinomycin D. This RNA is assumed to be a transcriptive intermediate form of viral RNA. Interferon mRNA appears in the cells 1 hour after virus induction and shows maximal activity after 6-8 hours. Its synthesis is inhibited by cycloheximide and actinomycin D.
在病毒诱导干扰素产生的过程中，细胞内会出现两种RNA。其中一种可诱导受体细胞产生具有后者细胞种属特异性的干扰素（干扰素诱导RNA），另一种则被用放线菌素D预处理过的受体细胞翻译为具有RNA供体细胞种属特异性的干扰素（干扰素mRNA）。干扰素诱导RNA在病毒诱导后20 - 30分钟出现，1小时后显示出最大活性。其形成不受环己酰亚胺或放线菌素D的影响。这种RNA被认为是病毒RNA的转录中间形式。干扰素mRNA在病毒诱导后1小时出现在细胞中，6 - 8小时后显示出最大活性。其合成受到环己酰亚胺和放线菌素D的抑制。
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