Henning S J
Environ Health Perspect. 1979 Dec;33:9-16. doi: 10.1289/ehp.79339.
In biochemical terms, the rat small intestine is relatively immature at birth and for the first two postnatal weeks. Then during the third week a dramatic array of enzymic changes begins, and by the end of the fourth week the intestine has the digestive and absorptive properties of the adult. Selective examples of these changes are discussed with emphasis on their implications for toxicological studies. The review also includes a detailed consideration of the roles of the dietary change of weaning and of glucocorticoid and thyroid hormones in the regulation of intestinal development.
从生化角度来看，大鼠小肠在出生时及出生后的前两周相对不成熟。在第三周，一系列显著的酶变化开始出现，到第四周结束时，小肠已具备成年动物的消化和吸收功能。本文将讨论这些变化的一些典型例子，并重点阐述它们对毒理学研究的意义。本综述还详细探讨了断奶时饮食变化以及糖皮质激素和甲状腺激素在肠道发育调节中的作用。
