Leonhard K
Int J Soc Psychiatry. 1979;25(4):285-94. doi: 10.1177/002076407902500407.
Concrete findings indicate the possibility of preventing schizophrenia, but it cannot be too strongly emphasized that the findings only relate to certain forms of theillness. Schizophrenias running an insidiously progressive course could very seldom be obsserved in monozygotic twins. So these pairs provide evidence that forms with this course can be prevented. It is to be supposed that the close communication usually found in identical twins, prevents withdrawal from environment and in consequence prevents schizophrenia. This assumption seems to be confirmed by our observation in insidiously progressive childhood schizophrenias which accumulate in only children and sometimes break out already in early childhood while the infants, staying in a hospital or a home, are suffering lack of communication. So it seems possible to prevent these forms of schizophrenia when we succeed in providing a close contact of the child and the adolescent with an intimate friend who directs his thinking outwards and protects him from withdrawal. But, unfortunately, in cases with phasic course the provoking factors correlate with the factors preventing the insidiously progressive forms. However, in detail, not quite the same factors prevent the one forms as precipitate the others, so that we can avoid doing harm simultaneously when we succeed in doing good. Besides, we must take account of the fact that some schizophrenias running a remitting course, especially periodic catatonia, are of hereditary origin and cannot be prevent psychosocially.
具体研究结果表明存在预防精神分裂症的可能性,但必须着重强调的是,这些结果仅适用于某些形式的该疾病。在同卵双胞胎中很少能观察到隐匿性进行性病程的精神分裂症。因此,这些双胞胎对提供了证据,表明这种病程形式的精神分裂症是可以预防的。据推测,同卵双胞胎中常见的密切交流能防止其脱离环境,从而预防精神分裂症。我们对隐匿性进行性儿童精神分裂症的观察似乎证实了这一假设,这类病症在独生子女中较为常见,有时在幼儿期就会发作,而此时婴儿因住院或在家中而缺乏交流。所以,当我们成功让儿童和青少年与一位能引导其向外思考并防止其脱离外界的亲密朋友建立密切联系时,似乎有可能预防这些形式的精神分裂症。然而,不幸的是,对于呈阶段性病程的病例,诱发因素与预防隐匿性进行性病程形式的因素相关。不过,具体而言,预防一种病程形式的因素与促使另一种病程形式发作的因素并不完全相同,所以当我们成功做好事时,能避免同时造成伤害。此外,我们必须考虑到这样一个事实,即一些呈缓解性病程的精神分裂症,尤其是周期性紧张症,是由遗传因素引起的,无法通过社会心理方式预防。