Guraya S S, Gupta S K
Z Mikrosk Anat Forsch. 1979;93(5):959-73.
A study has been made of the morphological and histochemical changes of the ovary of the field rat, Millardia meltada during its oestrous cycle and pregnancy. The follicular growth and atresia, ovulation and formation of corpora lutea occur throughout the year except severe winter months (December and January). Fluctuations in the follicular development occur on different days of the oestrous cycle and pregnancy. The granulosa cells show a progressive increase in their size in successive stages of follicle growth. The granulosae of normal follicles show some sparsely scattered lipid bodies which consist of phospholipids. Theca interna cells during follicular growth develop diffuse lipoproteins and lipid droplets consisting of triglycerides, phospholipids and cholesterol and/or its esters. The luteal cells of corpora lutea are formed by the granulosa cells as the theca interna cells degenerate and disappear. The fibroblast-like cells of thecal origin, alongwith the blood vessels, invade the luteal cell mass. The luteal cells during metoestrus, dioestrus and first half of pregnancy show abundant diffuse lipoproteins and a few lipid droplets composed mainly of phospholipids and some triglycerides, which are indicative of active steroidogenesis. The details of degenerative histological and histochemical alterations of corpora lutea during oestrous cycle and pregnancy are also described and discussed. Morphological and histochemical changes of follicular atresia are described. The granulosa cells of atretic follicle degenerate and disappear leaving behind theca interna cells which form patches of interstitial gland cells during the reproductive activity of the present rat. Interstitial gland cells show diffusely distributed sudanophilic lipoproteins and lipid droplets consisting of triglycerides, cholesterol and/or its esters and some phospholipids, which are indicative of steroidogenesis. The functional significance of histological and histochemical changes, which occur in various components of the ovary during oestrous cycle and pregnancy, has been discussed.
对野生大鼠（Millardia meltada）卵巢在发情周期和妊娠期的形态学及组织化学变化进行了研究。除了严冬月份（12月和1月）外，卵泡的生长、闭锁、排卵以及黄体的形成全年都会发生。在发情周期和妊娠期的不同日子，卵泡发育会出现波动。在卵泡生长的连续阶段，颗粒细胞的大小逐渐增加。正常卵泡的颗粒细胞显示出一些稀疏分布的脂质体，其由磷脂组成。卵泡生长期间的内膜细胞会形成弥散的脂蛋白和由甘油三酯、磷脂以及胆固醇和/或其酯组成的脂滴。随着内膜细胞退化和消失，黄体细胞由颗粒细胞形成。来自内膜的成纤维细胞样细胞与血管一起侵入黄体细胞团。在发情后期、间情期以及妊娠前半期，黄体细胞显示出丰富的弥散脂蛋白和一些主要由磷脂和一些甘油三酯组成的脂滴，这表明存在活跃的类固醇生成。还描述并讨论了发情周期和妊娠期黄体退化的组织学和组织化学改变的细节。描述了卵泡闭锁的形态学和组织化学变化。闭锁卵泡的颗粒细胞退化并消失，留下内膜细胞，在本研究大鼠的生殖活动期间，这些内膜细胞形成间质腺细胞斑。间质腺细胞显示出弥散分布的嗜苏丹脂蛋白和由甘油三酯、胆固醇和/或其酯以及一些磷脂组成的脂滴，这表明存在类固醇生成。讨论了发情周期和妊娠期卵巢各组成部分发生的组织学和组织化学变化的功能意义。
