Wildt D E, Panko W B, Seager S W
Prostaglandins. 1979 Dec;18(6):883-92. doi: 10.1016/0090-6980(79)90125-4.
The effect of prostaglandin F2 alpha (PGF2 alpha) on endocrine and ovarian function during the early luteal phase of the domestic cat was investigated. Queens were induced to ovulate and then injected subcutaneously with 0.5-5.0 mg PGF2 alpha/kg body weight. The greatest dose was found to approach toxicity. Concentrations of progesterone were similar in cats following treatment with PGF2 alpha compared to values of controls. Development and regression of corpora lutea as determined by serial laparoscopy were similar in all groups. These data indicate that PGF2 alpha at the tested dosages, given during the early luteal phase is not luteolytic in this species and suggest that these regimens would be ineffective for the premature termination of pseudopregnancy.
研究了前列腺素F2α（PGF2α）对家猫黄体早期内分泌和卵巢功能的影响。诱导母猫排卵，然后皮下注射0.5 - 5.0毫克PGF2α/千克体重。发现最大剂量接近毒性。与对照组相比，用PGF2α治疗的猫体内孕酮浓度相似。通过连续腹腔镜检查确定的黄体发育和退化在所有组中相似。这些数据表明，在黄体早期给予测试剂量的PGF2α对该物种无溶黄体作用，并表明这些方案对假孕的过早终止无效。
