Lenaz G, Bertoli E, Parenti-Castelli G, Sechi A M, Trigari G
Boll Soc Ital Biol Sper. 1979 Jun 30;55(11):1033-8.
Short chain ubiquinones (Q-3) uncouple oxidative phosphorylation in rat heart mitochondria, as shown by polarimetric experiments, and abolish P:O ratios in succinate driven oxidative phosphorylaton. The uncoupling is reversed by long chain ubiquinones (Q-7). Furthermore, short chain ubiquinones abolish oligomycin sensitivity of ATPase; the inhibition is restored by Q-7. The extraction of endogenous ubiquinone from mitochondria reversibly lowers oligomycin sensitivity of ATPase.
短链泛醌（Q-3）可使大鼠心脏线粒体中的氧化磷酸化解偶联，这在偏振实验中得到了证实，并且在琥珀酸驱动的氧化磷酸化过程中消除了P:O比值。长链泛醌（Q-7）可逆转这种解偶联作用。此外，短链泛醌消除了ATP酶对寡霉素的敏感性；Q-7可恢复这种抑制作用。从线粒体中提取内源性泛醌可使ATP酶对寡霉素的敏感性可逆性降低。
