Parenti-Castelli G, Degli Esposti M, Bertoli E, Lenaz G
Boll Soc Ital Biol Sper. 1979 Oct 15;55(19):1988-92.
Short-chain ubiquinone (UQ-3) abolishes oligomycin sensitivity of ATPase in submitochondrial particles and the effect is reversed by long-chain ubiquinone (UQ-7). Ubiquinone-3 also abolishes DCCD sensitivity of ATPase in submitochondrial particles but the effect is not reversed by long-chain ubiquinones. These data suggest that ubiquinone interferes with energy transfer process by interaction with mitochondrial ATPase.
短链泛醌(UQ - 3)可消除亚线粒体颗粒中ATP酶的寡霉素敏感性,且该效应可被长链泛醌(UQ - 7)逆转。泛醌 - 3还可消除亚线粒体颗粒中ATP酶的二环己基碳二亚胺(DCCD)敏感性,但该效应不能被长链泛醌逆转。这些数据表明,泛醌通过与线粒体ATP酶相互作用干扰能量转移过程。