Moore A, Ansell C, Barrie H
Br Med J. 1977 Jan 15;1(6054):129-31. doi: 10.1136/bmj.1.6054.129.
Most cows' milk based formulae for infant feeding present a greater acid load to the infant than breast milk. To determine the effect of this difference the acid base state of 180 healthy term infants was measured on the sixth day of life and related to the type of feed. Those infants fed on cows' milk formula (SMA) had a mean pH of 7-34 +/- 0-05 and a base deficit of 8-8 +/- 3-1, while those fed on breast milk had a mean pH of 7-38 +/- 0-05 and a base deficit of 5-6 +/- 3-1. The difference between the two groups of infants was significant for both these measurements. Metabolic acidosis was defined as a base deficit greater than 10 mmol/l. Seventy-four per cent of the 34 infants who were acidotic at six days were bottle-fed. There was a significant correlation between the pH of the feed and the degree of acidosis in the infant as measured by the base deficit. The findings suggest that when breast milk is not available a pH-adjusted milk formula would be desirable for preventing and treating neonatal metabolic acidosis.
大多数用于婴儿喂养的以牛乳为基础的配方奶粉给婴儿带来的酸负荷比母乳更大。为了确定这种差异的影响，在出生后第六天测量了180名健康足月儿的酸碱状态，并将其与喂养方式相关联。那些以牛乳配方奶粉（SMA）喂养的婴儿平均pH值为7.34±0.05，碱缺失为8.8±3.1，而那些以母乳喂养的婴儿平均pH值为7.38±0.05，碱缺失为5.6±3.1。两组婴儿在这两项测量上的差异均具有显著性。代谢性酸中毒定义为碱缺失大于10 mmol/L。在出生六天时发生酸中毒的34名婴儿中，74%是人工喂养的。通过碱缺失测量发现，喂养奶粉的pH值与婴儿酸中毒程度之间存在显著相关性。研究结果表明，当无法获得母乳时，调整pH值的牛奶配方奶粉对于预防和治疗新生儿代谢性酸中毒是可取的。
