内因子与其抗体的解离：在恶性贫血胃液标本研究中的应用
Dissociation of intrinsic factor from its antibody: application to study of pernicious anaemia gastric juice specimens.
作者信息
Rose M S, Chanarin I
出版信息
Br Med J. 1969 Feb 22;1(5642):468-70. doi: 10.1136/bmj.1.5642.468.
Abstract
Intrinsic factor antibody may sometimes be concealed in the gastric secretions of pernicious anaemia subjects, being complexed with residual amounts of intrinsic factor.A method is described for dissociating intrinsic factor from its antibody. Antibody to the vitamin-B(12)-binding site of intrinsic factor was identified in 16 (57%) out of 28 samples of pernicious anaemia gastric juice after dissociation but in only 10 before dissociation. There was no clear relationship between the incidence of antibody in the serum and in the gastric juice of these patients.
摘要
内因子抗体有时可能隐匿于恶性贫血患者的胃分泌物中，与残留的内因子结合。本文描述了一种将内因子与其抗体解离的方法。在28份恶性贫血胃液样本中，经解离后有16份（57%）检测出针对内因子维生素B₁₂结合位点的抗体，而解离前只有10份检测出。这些患者血清和胃液中抗体的发生率之间没有明显关联。
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本文引用的文献
1
Gastric intrinsic factor.胃内因子
Gut. 1968 Aug;9(4):373-5. doi: 10.1136/gut.9.4.373.
2
A METHOD FOR THE ASSAY OF HUMAN GASTRIC INTRINSIC FACTOR AND FOR THE DETECTION AND TITRATION OF ANTIBODIES AGAINST INTRINSIC FACTOR.一种检测人胃内因子的方法以及检测和滴定抗内因子抗体的方法。
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Effect of transplacental transfer of antibody to intrinsic factor.抗体经胎盘转移至内因子的作用。
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Occurrence in gastric juice of antibody to a complex of intrinsic factor and vitamin B12.胃内出现针对内因子与维生素B12复合物的抗体。
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An in vitro test for the detection of serum antibody to intrinsic factor--vitamin B12 complex.一种用于检测血清中内因子 - 维生素B12复合物抗体的体外试验。
J Lab Clin Med. 1966 Mar;67(3):510-5.
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Intrinsic factor antibodies and intrinsic factor mediated vitamin B-12 absorption in pernicious anaemia.内因子抗体与内因子介导的恶性贫血中维生素B-12吸收
Gut. 1965 Oct;6(5):436-8. doi: 10.1136/gut.6.5.436.
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Placental transfer of gastric antibodies.胃抗体的胎盘转运。
Lancet. 1967 Apr 1;1(7492):695-8. doi: 10.1016/s0140-6736(67)92178-2.
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Intrinsic -factor antibodies in gastric juice of pernicious - anemia patients.恶性贫血患者胃液中的内因子抗体
Lancet. 1966 Jul 9;2(7454):88-9. doi: 10.1016/s0140-6736(66)91811-3.
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