Leach S, Roy S S
Age Ageing. 1986 Jul;15(4):241-6. doi: 10.1093/ageing/15.4.241.
A total of 521 patients consecutively admitted to an acute geriatric unit were kept under surveillance by one observer during their stay. All drugs given to them and the occurrence of adverse events were recorded. One hundred and seventeen adverse drug reactions occurred in 94 patients representing 18.8% of the 500 patients receiving drugs. Thirteen of these reactions were considered severe. Each patient received an average of 6.1 drugs, not necessarily simultaneously. Altogether 212 different drug preparations were used. Diamorphine and insulin had the highest adverse reaction rates, diamorphine having the highest risk of a severe adverse reaction. Antibiotics and diuretics caused the most adverse reactions, and were by far the most commonly prescribed drugs (26.5% of the sample). Of the patients receiving eight or more drugs, 41% suffered an adverse drug reaction.
一位观察者对连续入住急性老年病科的521名患者在住院期间进行了全程监测。记录了他们所使用的所有药物以及不良事件的发生情况。在500名接受药物治疗的患者中，94名患者发生了117起药物不良反应，占18.8%。其中13起反应被认为是严重的。每位患者平均使用6.1种药物，不一定是同时使用。总共使用了212种不同的药物制剂。海洛因和美沙酮的不良反应发生率最高，海洛因发生严重不良反应的风险最高。抗生素和利尿剂引起的不良反应最多，并且是迄今为止最常用的药物（占样本的26.5%）。在接受8种或更多药物治疗的患者中，41%发生了药物不良反应。
