Epstein C J
Science. 1969 Mar 7;163(3871):1078-9. doi: 10.1126/science.163.3871.1078.
The glucose-6-phosphate dehydrogenase and lactate dehydrogenase contents of oocytes from XO and XX female mice have been measured. The activity of the former in the oocytes of XO mice is half of that in the oocytes of XX mice, whereas the lactate dehydrogenase activities in the two groups of ova are the same. These results indicate that glucose-6-phosphate dehydrogenase from a mouse oocyte is an X-linked enzyme, that its synthesis occurs in the oocyte and is dosage dependent, and that inactivation of the X chromosome does not occur in the mouse oocyte.
已对XO和XX雌性小鼠卵母细胞中的葡萄糖-6-磷酸脱氢酶和乳酸脱氢酶含量进行了测定。XO小鼠卵母细胞中前者的活性是XX小鼠卵母细胞中活性的一半，而两组卵子中的乳酸脱氢酶活性相同。这些结果表明，小鼠卵母细胞中的葡萄糖-6-磷酸脱氢酶是一种X连锁酶，其合成发生在卵母细胞中且具有剂量依赖性，并且X染色体在小鼠卵母细胞中不会发生失活。
