小鼠中类固醇硫酸酯酶X连锁的证据：XX和XO小鼠卵母细胞中的类固醇硫酸酯酶水平。
Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice.
作者信息
Gartler S M, Rivest M
出版信息
Genetics. 1983 Jan;103(1):137-41. doi: 10.1093/genetics/103.1.137.
Abstract
The steroid sulfatase (STS) levels in mature oocytes of XX and XO mice were assayed along with lactate dehydrogenase (LDH), an autosomal marker, and glucose-6-phosphate dehydrogenase (G6PD), a known X-linked gene. LDH levels in XX and XO oocytes were equal, whereas STS and G6PD levels were approximately twice as high in XX oocytes as in XO oocytes. These results indicate that the STS gene is X-linked in the mouse just as it is in humans. Assays of STS in kidney tissue of XX and XO mice indicated dosage compensation for the gene, which is different from that observed in humans.
摘要
对XX和XO小鼠成熟卵母细胞中的类固醇硫酸酯酶（STS）水平进行了测定，同时还测定了常染色体标记物乳酸脱氢酶（LDH）和已知的X连锁基因葡萄糖-6-磷酸脱氢酶（G6PD）。XX和XO卵母细胞中的LDH水平相等，而XX卵母细胞中的STS和G6PD水平大约是XO卵母细胞中的两倍。这些结果表明，STS基因在小鼠中与在人类中一样是X连锁的。对XX和XO小鼠肾脏组织中的STS进行测定表明该基因存在剂量补偿，这与在人类中观察到的情况不同。
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