Irvin A D, Brown C G, Kanhai G K, Stagg D A
Res Vet Sci. 1977 Jan;22(1):53-5.
Bovine lymphosarcoma cells, previously established in culture, were inoculated subcutaneously into groups of irradiated and non-irradiated athymic (nude) mice. Tumours developed at the site of inoculation in all of the irradiated mice but in none of the others. Tumour growth was progressive in all cases but there was no evidence of invasion of surrounding tissues nor of metastasis. Tumour cells were passaged directly to further mice and a similar growth pattern was recorded. The use of this system suggests a possible small animal laboratory model for bovine lymphosarcoma.
先前已在培养物中建立的牛淋巴肉瘤细胞，被皮下接种到经辐照和未经辐照的无胸腺（裸）小鼠组中。在所有经辐照的小鼠接种部位都出现了肿瘤，但其他小鼠均未出现。在所有情况下肿瘤生长都是渐进性的，但没有证据表明肿瘤侵犯周围组织或发生转移。肿瘤细胞直接接种到更多小鼠体内，记录到了类似的生长模式。该系统的应用提示了一种可能用于牛淋巴肉瘤研究的小型动物实验室模型。
