Nielsen K, Arrigoni-Martelli E
Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):267-72. doi: 10.1111/j.1600-0773.1977.tb02077.x.
Single and/or repeated administrations of bumetanide, bendroflumethiazide and hydralazine to normotensive and spontaneously hypertensive rats resulted in an increase of urinary kallikrein excretion. No correlation was found with sodium output. The role of the increased plasma renin activity is discussed and it is suggested that the activation of the renal kallikrein-kinin system is related to the increase in renal blood flow.
对正常血压和自发性高血压大鼠单次和/或重复给予布美他尼、苄氟噻嗪和肼苯哒嗪，导致尿激肽释放酶排泄增加。未发现与钠排出量相关。讨论了血浆肾素活性增加的作用，并提出肾激肽释放酶-激肽系统的激活与肾血流量增加有关。
