Korczyn A D, Laor N
Invest Ophthalmol Vis Sci. 1977 Mar;16(3):231-2.
A patient with Waardenburg syndrome had, in addition to the classical findings, a semidilated fixed pupil which did not react to changes of illumination, to convergence, or to pilocarpine of phospholine iodide. However, it responded normally to locally applied drugs acting on the sympathetic system. The pupil dilated after application of atropine, homatropine, or cocaine. The effect of cocaine, but not of atropine and homatropine, was prevented by pretreatment with guanethidine. It is concluded that the mydriasis caused by atropine and homatropine is partly dependent upon a direct action on the radial smooth muscle.
一名患有瓦登伯革氏综合征的患者，除了有典型的症状外，还出现了一只半扩张的固定瞳孔，该瞳孔对光照变化、集合反应或碘化磷酰胆碱毛果芸香碱均无反应。然而，它对局部应用的作用于交感神经系统的药物反应正常。应用阿托品、后马托品或可卡因后瞳孔扩大。可卡因的作用，但阿托品和后马托品的作用则不受胍乙啶预处理的影响。得出的结论是，阿托品和后马托品引起的瞳孔散大部分依赖于对放射状平滑肌的直接作用。
