Bonomi L, Perfetti S, Bellucci R, Massa F, De Franco I
Ann Ophthalmol. 1987 Apr;19(4):142-3, 145.
In this investigation, a rabbit model was used to study the effectiveness of topical diclofenac sodium in the prevention of miosis induced by manipulation of the ocular structures. In untreated rabbit eyes, paracentesis of the anterior chamber induced a 25% narrowing of the pupil. In atropine-treated rabbit eyes, the absolute pupil diameters were larger, but the pupil still contracted, resulting in a postoperative diameter of 6.5 mm. Pretreatment with diclofenac 0.1% eye drops effectively inhibited paracentesis-induced miosis; the postoperative pupil narrowing amounted to only 9% of the original diameter in both untreated and atropine-treated eyes. With a combined topical application of atropine and diclofenac, the mean pupil diameters after paracentesis were as large as 8.7 mm. Diclofenac seems to be a promising drug for the maintenance of mydriasis during eye surgery.
在本研究中，使用兔模型来研究局部应用双氯芬酸钠预防因眼部结构操作引起的瞳孔缩小的有效性。在未治疗的兔眼中，前房穿刺导致瞳孔缩小25%。在阿托品治疗的兔眼中，绝对瞳孔直径较大，但瞳孔仍会收缩，术后直径为6.5毫米。用0.1%双氯芬酸钠滴眼液预处理可有效抑制穿刺引起的瞳孔缩小；在未治疗和阿托品治疗的眼中，术后瞳孔缩小仅为原始直径的9%。联合局部应用阿托品和双氯芬酸钠，穿刺后的平均瞳孔直径高达8.7毫米。双氯芬酸钠似乎是一种在眼科手术期间维持瞳孔散大的有前景的药物。
