组织移植中抗原敏感细胞的频率。关于克隆选择的评论。
The frequency of antigen-sensitive cells in tissue transplantation. A commentary on clonal selection.
作者信息
Nisbet N W, Simonsen M, Zaleski M
出版信息
J Exp Med. 1969 Mar 1;129(3):459-67. doi: 10.1084/jem.129.3.459.
Abstract
Graft-vs.-host (GVH) reactions were performed in chicken embryos by intravenous injection of adult chicken blood dilutions, and the result was scored by weighing the spleens as well as by karyological identification of host and donor metaphases. From the frequency of detectable signs of GVH reaction when low doses of donor cells were injected into hosts containing one foreign allele of the B locus it is concluded that 1-2% must be a minimum estimate for the frequency of antigen-sensitive cells of a given specificity in this system. It is not found possible to reconcile the findings with the strictest form of clonal selection which postulates a single receptor specificity per clone of antigen-sensitive cells.
摘要
通过静脉注射成年鸡血液稀释液在鸡胚中进行移植物抗宿主（GVH）反应，并通过称量脾脏以及对宿主和供体中期染色体进行核型鉴定来对结果进行评分。当将低剂量供体细胞注入含有B位点一个外源等位基因的宿主中时，从可检测到的GVH反应迹象的频率得出结论，在该系统中，对于给定特异性的抗原敏感细胞频率，1 - 2%必定是最低估计值。未发现能够将这些发现与克隆选择最严格形式相协调，克隆选择最严格形式假定每个抗原敏感细胞克隆具有单一受体特异性。
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本文引用的文献
1
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Nature. 1964 Oct 10;204:151-5. doi: 10.1038/204151a0.
2
A sex difference in the splenomegaly syndrome in chick embryos injected with adult spleen cells or blood.
Exp Cell Res. 1962 Oct;28:151-7. doi: 10.1016/0014-4827(62)90324-5.
3
Leukocyte culture for chromosome studies in the domestic fowl.用于家鸡染色体研究的白细胞培养
Stain Technol. 1963 Jan;38:54-6.
4
Primary immune response in grafted cells. Dissociation between the proliferation of activity and the proliferation of cells.移植细胞中的初次免疫反应。活性增殖与细胞增殖之间的分离。
J Exp Med. 1967 Jun 1;125(6):967-81. doi: 10.1084/jem.125.6.967.
5
The carriage of immunological memory by small lymphocytes in the rat.大鼠中小淋巴细胞的免疫记忆携带情况。
J Exp Med. 1966 Nov 1;124(5):1017-30. doi: 10.1084/jem.124.5.1017.
6
Karyotype studies on Gallus domesticus.家鸡的核型研究。
Chromosoma. 1965 May 26;16(5):601-8. doi: 10.1007/BF00326975.
7
Alloantibody production measured by plaque assay in relation to strong and weak histoincompatibility.通过空斑试验测定的同种抗体产生与强组织相容性和弱组织相容性的关系。
J Exp Med. 1966 Nov 1;124(5):885-900. doi: 10.1084/jem.124.5.885.
8
Current concepts of the immunological function of the thymus.胸腺免疫功能的当前概念。
Physiol Rev. 1967 Jul;47(3):437-520. doi: 10.1152/physrev.1967.47.3.437.
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