Lee H W, Kim S, Paik W K
Acta Endocrinol (Copenh). 1977 Apr;84(4):789-94. doi: 10.1530/acta.0.0840789.
Adrenalectomy induces a hypersensitivity in the rat to ammonia intoxication. Daily injection of hydrocortisone hydrochloride to adrenalectomized rats restored normal sensitivity to ammonia intoxication, with concomitant restoration of liver urea-synthesizing capacity to the normal value. When injected with a large dose of ammonium acetate, hydrocortisone-treated adrenalectomized rats were able to reduce the plasma ammonia concentration much more rapidly than the adrenalectomized control rats. However, neither the increase in liver urea synthesis nor the more rapid decrease in the plasma ammonia concentration were sufficient to explain the protective aciton of hydrocortisone against ammonia intoxication.
肾上腺切除术可使大鼠对氨中毒产生超敏反应。每日给肾上腺切除的大鼠注射盐酸氢化可的松可恢复其对氨中毒的正常敏感性，同时肝脏尿素合成能力也恢复至正常水平。当注射大剂量醋酸铵时，经氢化可的松治疗的肾上腺切除大鼠比肾上腺切除的对照大鼠能更迅速地降低血浆氨浓度。然而，肝脏尿素合成的增加和血浆氨浓度的更快降低都不足以解释氢化可的松对氨中毒的保护作用。
