Verjans H L, Eik-Nes K B
Acta Endocrinol (Copenh). 1977 Apr;84(4):829-41. doi: 10.1530/acta.0.0840829.
The effects of subcutaneous administration of graded doses of C19 (androstene or androstane) steroids on serum levels of LH and FSH and on weights of accessory reproductive organs in gonadectomized, adult male rats were investigated. The C19 steroids were administered during 7 days in doses of 100, 50, 25, 12.5 or 6.25 mug per 100 g body weight per day. With the amounts of steroids used, 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol had a high potency in preventing the rise of serum gonadotrophin concentrations and in curbing the decrease weights of ventral prostates and seminal vesicles following orchidectomy. 5alpha-Androstane-3beta, 17beta-diol showed no such effects. Positive feedback effects on serum gonadotrophins in castrates were observed following injection of certain doses of some steroids. Effects of steroids on accessory reprosuctive organs did not always correlate with those on gonadotrophic function of the hypothalamic-pituitary unit.
研究了皮下注射不同剂量的C19（雄烯或雄烷）类固醇对去势成年雄性大鼠血清促黄体生成素（LH）和促卵泡生成素（FSH）水平以及附属生殖器官重量的影响。C19类固醇连续7天给药，剂量为每天每100克体重100、50、25、12.5或6.25微克。在所使用的类固醇剂量下，5α-双氢睾酮和5α-雄烷-3α，17β-二醇在预防血清促性腺激素浓度升高以及抑制睾丸切除术后腹侧前列腺和精囊重量减轻方面具有高效能。5α-雄烷-3β，17β-二醇未显示出此类作用。注射某些剂量的一些类固醇后，观察到对去势大鼠血清促性腺激素有正反馈作用。类固醇对附属生殖器官的作用并不总是与对下丘脑-垂体单位促性腺功能的作用相关。
