Warnock M L, Kunzmann A
Arch Pathol Lab Med. 1977 Apr;101(4):180-6.
The small muscular pulmonary arteries are thought to be normal in obstructive pulmonary disease despite prolonged hypoxic stimulation to medial thickening. Because measurements on nondistended vessels have considerable variability, we reinvestigated the problem by studying the percentage of wall thickness of distended arteries in lungs taken post mortem from 5 asymptomatic emphysematous patients and 11 symptomatic patients with obstructive pulmonary disease. Vessels in the former patients had normal medial thicknesses. In contrast, we found an elevated mean percentage of wall thickness for vessels between 0.3 and 2.0 mm in diameter of 4.46% +/-1.44% (mean +/-SD) for patients with obstructive airways disease. Obstructive pulmonary disease, therefore, produced medial hypertrophy in small muscular arteries similar to that seen in other conditions associated with chronic hypoxia.
尽管长期处于低氧刺激下导致中膜增厚，但人们认为小肌性肺动脉在阻塞性肺疾病中是正常的。由于对未扩张血管的测量存在相当大的变异性，我们通过研究从5名无症状肺气肿患者和11名有症状阻塞性肺疾病患者尸检获得的肺脏中扩张动脉的壁厚百分比，重新研究了这个问题。前一组患者的血管中膜厚度正常。相比之下，我们发现阻塞性气道疾病患者直径在0.3至2.0毫米之间的血管壁厚平均百分比升高，为4.46%±1.44%（平均值±标准差）。因此，阻塞性肺疾病会导致小肌性动脉中膜肥厚，类似于在其他与慢性低氧相关的病症中所见。
