Meran A
Arch Otorhinolaryngol. 1977 Feb 15;214(4):351-9. doi: 10.1007/BF00457476.
The present paper is based on an exact analysis of the neurootological findings in 30 cases of multiple sclerosis (MS). Ms-diagnosis was verified using Schumacher's criteria and cerebro-spinal fluid findings. Central vestibular disorders were found in most of the cases. From our observation it may be assumed that the brainstem is an early site of involvement causing imbalance which can only be verified by an accurate neuro-otological evaluation. The most important pathological findings are the following: central spontaneous nystagmus, gaze-deviation nystagmus, positional nystagmus, disinhibition of induced (caloric and galvanic) nystagmus, delay of the reversal phenomenon of galvanic nystagmus,dysrhythmia as well as distorted optokinetic nystagmus. An extensive neuro-otological investigation is of clinical importance with respect to detecting cases of MS at an early stage of this disease.
本文基于对30例多发性硬化症(MS)患者神经耳科学检查结果的精确分析。MS诊断依据舒马赫标准及脑脊液检查结果得以证实。多数病例存在中枢性前庭功能障碍。从我们的观察来看,可以推测脑干是早期受累部位,会导致失衡,而这只能通过精确的神经耳科学评估来证实。最重要的病理表现如下:中枢性自发性眼球震颤、凝视偏斜性眼球震颤、位置性眼球震颤、诱发性(冷热试验及直流电刺激)眼球震颤抑制解除、直流电刺激眼球震颤反转现象延迟、节律异常以及视动性眼球震颤畸变。就早期发现MS病例而言,全面的神经耳科学检查具有临床重要性。