Schöneshöfer M, L'age M, Oelkers W
Acta Endocrinol (Copenh). 1977 May;85(1):109-17. doi: 10.1530/acta.0.0850109.
In 4 young healthy males, serum levels of 11-deoxycortisol (S), cortisol (F), 11-deoxycorticosterone (DOC) and corticosterone (B) were determined at short intervals after oral administration of 30 mg/kg of metyrapone (M) at midnight. 11-hydroxylase blockade was calculated from the formula (formula: see text). Significant blockade was demonstrable 15 to 30 min after drug administration. Maximum blockade (greater than 90%) was found between 2 and 4 a.m., and fell to 60-70% at 8 a.m. The profile of blockade was very similar in all the subjects, although the absolute early rise in steroid levels showed large inter-individual differences. The F level at 8 a.m. (only slightly suppressed under these conditions) is not a safe indicator of adequate 11-hydroxylase blockade.
在4名年轻健康男性中，于午夜口服30mg/kg美替拉酮（M）后，短时间内测定血清中11-脱氧皮质醇（S）、皮质醇（F）、11-脱氧皮质酮（DOC）和皮质酮（B）的水平。11β-羟化酶阻滞率根据公式（公式：见原文）计算得出。给药后15至30分钟可证实有显著阻滞。最大阻滞（大于90%）出现在凌晨2点至4点之间，上午8点时降至60 - 70%。尽管类固醇水平的绝对早期升高显示出个体间的巨大差异，但所有受试者的阻滞情况非常相似。上午8点时的F水平（在这些条件下仅略有抑制）并非11β-羟化酶充分阻滞的安全指标。
