Boedts D, Ars B
Arch Otorhinolaryngol. 1977 Mar 8;215(1):55-9. doi: 10.1007/BF00463191.
Basic information on the healing process of tympanic membrane perforations is scarce and sometimes contradictory. So the histological and histopathological course of the closure of tympanic membrane perforations was studied in experiments on mice and hamsters. From this investigations it seems evident that traumatic tympanic membrane perforations close nearly always spontaneously in animals. This fact must be kept in mind in the evaluation of techniques and results of tympanoplasties in animal experiments. Furthermore the squamous epithelium of the eardrum plays an important role in the regeneration of tympanic perforations. The closure of the connective tissue defect has always a tendency to lay behind the healing of the epithelial layer. This mechanism differs from the normal healing process of skin wounds where the squamous epithelium migrates over a newly formed granulation tissue layer. On the basis of these findings some practical considerations can be made on tympanoplasties in human.
关于鼓膜穿孔愈合过程的基础信息匮乏，且有时相互矛盾。因此，在小鼠和仓鼠实验中研究了鼓膜穿孔闭合的组织学和组织病理学过程。从这些研究中似乎可以明显看出，外伤性鼓膜穿孔在动物中几乎总是能自发闭合。在评估动物实验中鼓室成形术的技术和结果时必须牢记这一事实。此外，鼓膜的鳞状上皮在鼓膜穿孔的再生中起重要作用。结缔组织缺损的闭合总是倾向于落后于上皮层的愈合。这种机制不同于皮肤伤口的正常愈合过程，在皮肤伤口中鳞状上皮会在新形成的肉芽组织层上迁移。基于这些发现，可以对人类鼓室成形术进行一些实际的考虑。
