冷冻疗法在避免大鼠鼓膜切开术闭合方面的有效性。
Efficiency of cryotherapy in avoiding myringotomy closure in rats.
作者信息
Chirteş Felician, Trombitas Veronica, Vlad Diana, Tabaran Flaviu, Berce Cristian, Albu Silviu
机构信息
ENT Department, Military Hospital, Cluj-Napoca, Romania.
Otolaryngology Head and Neck Surgery Department, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
出版信息
Indian J Otolaryngol Head Neck Surg. 2015 Mar;67(1):68-71. doi: 10.1007/s12070-014-0782-7. Epub 2014 Oct 17.
Myringotomy and ventilation tube placement is an office-based procedure and represents the treatment of choice for middle ear effusions and for transtympanic drug administration. The aim of our study was to study the efficiency of low-pressure spray cryotherapy on protraction of patency time of myringotomies in rats. Bilateral myringotomies were performed with cold instruments. Afterward, one ear in each rat was randomly assigned for liquid nitrogen treatment of the perforated eardrum. Myringotomy patency was recorded daily and histological analysis of the eardrums was performed. In the myringotomy group patency time was 4.75 ± 2.93 days, while in the cryotherapy group was 11.01 ± 4.87 days. The difference is statistically significant: Student t test, p < 0.00001, 95 % CI (-8.82; -3.67). Moreover, according to Kaplan-Meier method, myringotomy survival is significantly longer in the cryotherapy group. The healing processes of the cryotreated eardrums last longer and the patency of myringotomy was longer as compared to untreated myringotomies.
鼓膜切开置管术是一种门诊手术，是治疗中耳积液和经鼓膜给药的首选方法。我们研究的目的是探讨低压喷雾冷冻疗法对延长大鼠鼓膜切开术通畅时间的效果。使用冷器械进行双侧鼓膜切开术。之后，每只大鼠的一只耳朵被随机分配接受液氮处理穿孔鼓膜。每天记录鼓膜切开术的通畅情况，并对鼓膜进行组织学分析。鼓膜切开术组的通畅时间为4.75±2.93天，而冷冻治疗组为11.01±4.87天。差异具有统计学意义：学生t检验，p<0.00001，95%置信区间（-8.82；-3.67）。此外，根据Kaplan-Meier方法，冷冻治疗组鼓膜切开术的存活时间明显更长。与未治疗的鼓膜切开术相比，冷冻处理的鼓膜愈合过程持续时间更长，鼓膜切开术的通畅时间也更长。
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