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1
Immediate fibrinolytic effect of components from the interior of human cells.人细胞内部成分的即时纤溶作用。
Br J Exp Pathol. 1969 Apr;50(2):153-7.
2
Action of 3,4,5-trimethoxybenzoyl-epsilon-amino caproic acid on platelet aggregation and on the activation of plasminogen by streptokinase.3,4,5-三甲氧基苯甲酰-ε-氨基己酸对血小板聚集及链激酶激活纤溶酶原的作用。
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Studies on fluidity of blood on the basis of fibrinolysis. 8. Analysis of fibrinolytic activity of the human blood activated with streptokinase and urokinase in vitro--with special reference to its similarity to fibrinolytic activity of fluid corpse blood.基于纤维蛋白溶解的血液流动性研究。8. 体外链激酶和尿激酶激活的人血纤维蛋白溶解活性分析——特别参考其与流动尸体血液纤维蛋白溶解活性的相似性。
Nihon Hoigaku Zasshi. 1971 Sep;25(3):366-72.
6
[On the problem of postmortem fibrinolysis. Activation and inhibition of postmortem fibrinolysis with streptokinase and epsilon-aminocaprioic acid].[关于死后纤维蛋白溶解问题。链激酶和ε-氨基己酸对死后纤维蛋白溶解的激活与抑制作用]
Blut. 1965 Sep;11(6):345-51. doi: 10.1007/BF01631766.
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8
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[Studies of leukocytic fibrinolysis].[白细胞纤维蛋白溶解的研究]
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引用本文的文献

1
Immediate effect of components from the interior of human cells on blood coagulation.
Ir J Med Sci. 1971 Feb;140(2):60-70. doi: 10.1007/BF02937174.
2
The ultrastructure of the lysis of fibrin by endothelium in vitro.体外内皮细胞溶解纤维蛋白的超微结构
Br J Exp Pathol. 1974 Apr;55(2):138-48.

本文引用的文献

1
ACTIVATION OF PROPLASMIN BY A FACTOR FROM MAMMALIAN TISSUE.来自哺乳动物组织的一种因子对纤溶酶原的激活作用。
J Clin Invest. 1950 Mar;29(3):317-24. doi: 10.1172/JCI102260.
2
Studies on a proteolytic enzyme system of the blood. II. Fibrinolysokinase activators for profibrinolysin.血液中蛋白水解酶系统的研究。II. 纤维蛋白溶酶原的纤维蛋白溶激酶激活剂。
J Clin Invest. 1950 Aug;29(8):1059-68. doi: 10.1172/JCI102337.
3
INTRACELLULAR LOCATION OF TISSUE THROMBOPLASTIN AND POSSIBLE RELATION TO FIBRIN DEPOSITS IN HUMAN NEOPLASMS.组织凝血活酶在人肿瘤中的细胞内定位及其与纤维蛋白沉积的可能关系
Nature. 1965 Feb 6;205:608-10. doi: 10.1038/205608a0.
4
The fibrinolytic activity of the human endometrium.人子宫内膜的纤溶活性。
Acta Endocrinol (Copenh). 1956 Oct;23(2):207-18. doi: 10.1530/acta.0.0230207.
5
A study of cytofibrinokinase and fibrinolysin in extracts of tissue from human myometrium, endometrium, decidua, and placenta.一项关于人子宫肌层、子宫内膜、蜕膜和胎盘组织提取物中细胞纤维蛋白激酶和纤维蛋白溶酶的研究。
Am J Obstet Gynecol. 1956 Feb;71(2):342-9. doi: 10.1016/s0002-9378(16)37597-4.
6
Heat denaturation of plasminogen in the fibrin plate method.纤维蛋白平板法中纤溶酶原的热变性
Acta Physiol Scand. 1953 Feb 28;27(4):371-6. doi: 10.1111/j.1748-1716.1953.tb00951.x.
7
An activator system in blood indispensable for formation of plasmin by streptokinase.血液中一种对链激酶形成纤溶酶必不可少的激活剂系统。
Proc Soc Exp Biol Med. 1953 Feb;82(2):264-8. doi: 10.3181/00379727-82-20087.
8
The fibrin plate method for estimating fibrinolytic activity.用于评估纤维蛋白溶解活性的纤维蛋白平板法。
Arch Biochem Biophys. 1952 Oct;40(2):346-51. doi: 10.1016/0003-9861(52)90121-5.
9
Microthrombosis in injured and burned patients.受伤和烧伤患者的微血栓形成。
J Pathol Bacteriol. 1967 Jan;93(1):275-93. doi: 10.1002/path.1700930126.
10
[Intracellular localization and purification of a tissue proactivator of human plasminogen].[人纤溶酶原组织激活剂的细胞内定位与纯化]
C R Acad Hebd Seances Acad Sci D. 1965 Aug 18;261(7):1767-70.

人细胞内部成分的即时纤溶作用。

Immediate fibrinolytic effect of components from the interior of human cells.

作者信息

Clarke N, Collins M

出版信息

Br J Exp Pathol. 1969 Apr;50(2):153-7.

PMID:5772068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072159/
Abstract

Human chorion cells have been broken open and separated into “nuclear”, “mitochondrial”, “microsomal” and soluble fractions by differential centrifugation in the cold. Minute quantities of the homogenate and individual cell fractions were immediately tested for their fibrinolytic activity on fibrin plates with and without plasminogen, and also in the presence of streptokinase, ε-aminocaproic acid or Triton X-100. With the technique employed, no direct fibrinolysis was produced by the homogenate or cell fractions. In the presence of streptokinase the homogenate and cell fractions led to marked fibrinolysis indicating the presence of cellular proactivator activity. Comparison of the intracellular fractions indicated that the greatest proactivator activity was associated with the “microsomal fraction”. The streptokinase-induced proactivator activity was partly inhibited by certain concentrations of ε-aminocaproic acid.

摘要

人绒毛膜细胞已被破碎，并通过在低温下进行差速离心分离成“细胞核”、“线粒体”、“微粒体”和可溶性部分。立即对微量的匀浆和各个细胞部分在有和没有纤溶酶原的情况下以及在存在链激酶、ε-氨基己酸或曲拉通X-100的情况下在纤维蛋白平板上的纤溶活性进行了测试。采用该技术，匀浆或细胞部分未产生直接的纤维蛋白溶解作用。在链激酶存在的情况下，匀浆和细胞部分导致明显的纤维蛋白溶解，表明存在细胞前激活剂活性。细胞内部分的比较表明，最大的前激活剂活性与“微粒体部分”相关。链激酶诱导的前激活剂活性被一定浓度的ε-氨基己酸部分抑制。