Jackson D V, Richards F, Cooper M R, Ferree C, Muss H B, White D R, Spurr C L
JAMA. 1977 Jun 20;237(25):2730-3.
Twenty-nine patients with small cell carcinoma of the lung and without evidence of brain metastasis were randomized into two treatment groups consisting of 14 patients who received prophylactic cranial irradiation (PCI) and 15 who received none (non-PCI). All patients were treated with irradiation of the primary lesion and concomitant chemotherapy. The response rate and median survival of the two groups were not significantly different: 93% and 7.2 months in the non-PCI; 86% and 9.8 months in the PCI; P larger than or equal to .05. Brain metastasis occurred in 0/14 patients in the PCI and 4/15 in the non-PCI (P less than or equal to .05) and was the cause of major neurologic disability in each. Although PCI did not improve response rate or survival, brain metastasis with its attendant neurologic complications was effectively prevented.
29例无脑转移证据的小细胞肺癌患者被随机分为两个治疗组，其中14例接受预防性颅脑照射（PCI），15例未接受（非PCI）。所有患者均接受原发灶照射及同步化疗。两组的缓解率和中位生存期无显著差异：非PCI组分别为93%和7.2个月；PCI组分别为86%和9.8个月；P≥0.05。PCI组14例患者中0例发生脑转移，非PCI组15例中有4例发生（P≤0.05），且均导致严重神经功能障碍。尽管PCI未提高缓解率或生存率，但有效预防了脑转移及其伴随的神经并发症。
